LYMPHOID NEOPLASIA A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease
نویسندگان
چکیده
1The Feinstein Institute for Medical Research, North Shore-LIJ Health System, Manhasset, NY; 2Department of Medicine, Long Island Jewish Medical Center, North Shore-LIJ Health System, New Hyde Park, NY; 3Department of Medicine, Albert Einstein College of Medicine, Bronx, NY; 4Department of Medicine, North Shore University Hospital, North Shore-LIJ Health System, Manhasset, NY; 5Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD; 6Cancer Centre Karolinska, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden; 7Department of Medicine, NYU School of Medicine, New York, NY; and 8Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY
منابع مشابه
A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease.
Chronic lymphocytic leukemia (CLL) is an incurable adult disease of unknown etiology. Understanding the biology of CLL cells, particularly cell maturation and growth in vivo, has been impeded by lack of a reproducible adoptive transfer model. We report a simple, reproducible system in which primary CLL cells proliferate in nonobese diabetes/severe combined immunodeficiency/γc(null) mice under t...
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تاریخ انتشار 2011